Recent Advances in the Synthesis of 2,2′-Bipyridines and Their Derivatives

Abstract The sustained interest in the synthesis of new analogues 2,2′-bipyridines is supported by importance compounds featuring bipyridine core diverse areas chemical, biomedical and materials research, which relayed into development approaches expansion existing synthetic methods. This short review covers advances 2,2′-bipyridines, including both with a given substitution pattern methods for assembling core. Special attention directed toward use pyridine N-oxides metal-free protocols to facilitate formation bipyridines. focuses primarily on reports published last 5–6 years. 1 Introduction 2 Ullmann-Type Homocoupling Reactions 3 Cross-Coupling Synthesis Bipyridines 4 Coupling Employing Pyridine N-Oxides 5 Other Methods 2,2′-Bipyridines 6 Conclusions Outlook